  {"id":14501,"date":"2016-11-14T18:28:45","date_gmt":"2016-11-14T23:28:45","guid":{"rendered":"https:\/\/digital.hbs.edu\/platform-rctom\/submission\/3d-bioprinting-effective-testing-now-and-maybe-organ-printing-in-the-future\/"},"modified":"2016-11-14T18:28:45","modified_gmt":"2016-11-14T23:28:45","slug":"3d-bioprinting-at-organovo-effective-testing-now-and-maybe-organ-printing-in-the-future","status":"publish","type":"hck-submission","link":"https:\/\/d3.harvard.edu\/platform-rctom\/submission\/3d-bioprinting-at-organovo-effective-testing-now-and-maybe-organ-printing-in-the-future\/","title":{"rendered":"3D-Bioprinting at Organovo: Effective testing now and maybe organ \u201cprinting\u201d in the future?"},"content":{"rendered":"<p>3D printing is the process of producing a 3-D physical object from a design created using computer aided design software (CAD). <a href=\"#_ftn1\" name=\"_ftnref1\">[1]<\/a> 3D printing works on a principle called additive manufacturing, where each layer of the physical object is added one by one<a href=\"#_ftn2\" name=\"_ftnref2\">[2]<\/a> ;each layer could be thought of as one part of a horizontal cross-section of the full structure.<a href=\"#_ftn3\" name=\"_ftnref3\">[3]<\/a> In the medical biotechnology industry, 3D printing is used to develop tissue-like structures that could be used in a wide range of areas including evaluating the effect of drugs, developing organ replicas, and making implants and prosthetics.<a href=\"#_ftn4\" name=\"_ftnref4\">[4]<\/a><\/p>\n<p>Organovo is the first company in the world to have developed and commercialized the 3D bioprinter. <a href=\"#_ftn5\" name=\"_ftnref5\">[5]<\/a> 3D bioprinting helps (1) surgeons make critical decisions and (2) pharmaceutical companies test their new drugs quickly and more cheaply, allowing these companies to quickly cut off further investments in less promising drugs and invest more in promising drugs. <a href=\"#_ftn6\" name=\"_ftnref6\">[6]<\/a><\/p>\n<p>Organovo\u2019s process can be summarized as follows:<\/p>\n<ul>\n<li>Identify the structure and makeup of the tissue of interest and develop a design using software.<a href=\"#_ftn7\" name=\"_ftnref7\">[7]<\/a><\/li>\n<li>Isolate the cells from the tissue and allow them to grow and multiply in a medium.<a href=\"#_ftn8\" name=\"_ftnref8\">[8]<\/a><\/li>\n<li>\u201cBio ink\u201d is created through a unique process by combining cells from the previous step with building blocks.<a href=\"#_ftn9\" name=\"_ftnref9\">[9]<\/a><\/li>\n<li>The bio ink is inserted into this printer and software script\u00a0is run to make the printer create the physical object layer by layer.<a href=\"#_ftn10\" name=\"_ftnref10\">[10]<\/a> <a href=\"#_ftn11\" name=\"_ftnref11\">[11]<\/a><\/li>\n<\/ul>\n<p style=\"text-align: center\">Exhibit 1 &#8211; Organovo&#8217;s step-by-step process (image and video)<\/p>\n<p><a href=\"https:\/\/d3.harvard.edu\/platform-rctom\/wp-content\/uploads\/sites\/4\/2016\/11\/Screen-Shot-2016-11-14-at-5.40.52-PM-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-14504 aligncenter\" src=\"https:\/\/d3.harvard.edu\/platform-rctom\/wp-content\/uploads\/sites\/4\/2016\/11\/Screen-Shot-2016-11-14-at-5.40.52-PM-1-1024x632.png\" alt=\"Organovo's process step-by-step\" width=\"617\" height=\"381\" srcset=\"https:\/\/d3.harvard.edu\/platform-rctom\/wp-content\/uploads\/sites\/4\/2016\/11\/Screen-Shot-2016-11-14-at-5.40.52-PM-1-1024x632.png 1024w, https:\/\/d3.harvard.edu\/platform-rctom\/wp-content\/uploads\/sites\/4\/2016\/11\/Screen-Shot-2016-11-14-at-5.40.52-PM-1-300x185.png 300w, https:\/\/d3.harvard.edu\/platform-rctom\/wp-content\/uploads\/sites\/4\/2016\/11\/Screen-Shot-2016-11-14-at-5.40.52-PM-1-768x474.png 768w, https:\/\/d3.harvard.edu\/platform-rctom\/wp-content\/uploads\/sites\/4\/2016\/11\/Screen-Shot-2016-11-14-at-5.40.52-PM-1-600x370.png 600w, https:\/\/d3.harvard.edu\/platform-rctom\/wp-content\/uploads\/sites\/4\/2016\/11\/Screen-Shot-2016-11-14-at-5.40.52-PM-1.png 1118w\" sizes=\"auto, (max-width: 617px) 100vw, 617px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center\"><iframe loading=\"lazy\" title=\"The Bioprinting Process\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/s3CiJ26YS_U?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>3D bioprinting provides the following advantages over traditional processes:<\/p>\n<ul>\n<li><u>Customization<\/u> \u2013 3D bioprinters can produce highly customized replicas of human body parts such as organs, which surgeons can use to make critical decisions during surgery. <a href=\"#_ftn12\" name=\"_ftnref12\">[12]<\/a> For example, in 2015, 3D printing allowed surgeons to successful perform open-heart surgery on a four-year-old girl. <a href=\"#_ftn13\" name=\"_ftnref13\">[13]<\/a>The replica built through 3D printing enabled the surgeons to understand the specific complications of this girl\u2019s heart and subsequently perform a successful surgery. In Orthopedics and hearing aids (99% of hearing aids are made using 3d printing), 3d bioprinting, with its\u2019 focus on customization, is useful since one-size fits all implants don\u2019t always match each patient\u2019s unique characteristics.<a href=\"#_ftn14\" name=\"_ftnref14\">[14]<\/a><\/li>\n<li><u>Alternative to human\/animal testing<\/u> \u2013 Testing a new drug directly on humans\/animals has drawbacks \u2013- it is time consuming, expensive, and the side effects and efficacy are unknown. Organovo addresses these problems through 3d bioprinting. Organovo established a partnership with L\u2019Or\u00e9al to 3D print living human skin cells. <a href=\"#_ftn15\" name=\"_ftnref15\">[15]<\/a> This would allow L\u2019Or\u00e9al to safely test for toxicity and efficacy of its skin-care products, without animal tests. Organovo also signed a deal with Merck to develop a 3D printed liver for toxicity testing. <a href=\"#_ftn16\" name=\"_ftnref16\">[16]<\/a><\/li>\n<li><u>Higher speed<\/u> \u20133D printing takes considerably lesser time than conventional production processes, which necessitate extra steps such as milling and forging.<a href=\"#_ftn17\" name=\"_ftnref17\">[17]<\/a> 3D printing is much quicker in making prototypes since it doesn\u2019t require additional pre-production setup steps to make new prototypes; these steps will be required for traditional production methods. <a href=\"#_ftn18\" name=\"_ftnref18\">[18]<\/a><\/li>\n<li><u>Environmentally Friendly\/ Lesser Wastage<\/u> \u2013 3D printing is an additive process and, thus, no excess material is used, only what is required for each layer is used. Thus there is minimal waste here, unlike subtractive manufacturing processes where there is wastage since the final product is shaped out from a larger initial product.<a href=\"#_ftn19\" name=\"_ftnref19\">[19]<\/a><\/li>\n<\/ul>\n<p>I believe Organovo should do the following:<\/p>\n<ul>\n<li><u>Reduce costs<\/u>: While 3D printing is more cost effective and faster for small production runs, for larger production runs, 3D printing does not maintain these advantages over traditional production processes. <a href=\"#_ftn20\" name=\"_ftnref20\">[20]<\/a> <a href=\"#_ftn21\" name=\"_ftnref21\">[21]<\/a> Organovo needs to find a way to profitably scale 3D printing. Only by producing larger volumes can it cover its high R&amp;D costs.<\/li>\n<li><u>Modifying manufacturing processes to overcome structural weaknesses<\/u>: Structures developed using the additive process in 3D printers may exhibit some amount of structural weaknesses compared to traditional processes.<a href=\"#_ftn22\" name=\"_ftnref22\">[22]<\/a> For Healthcare purposes, safety is very important and since Organovo plans to develop structures to be inserted into humans in the future, it should adopt processes that increase structural strength.<\/li>\n<li><u>Increasing adoption:<\/u> Some pharmaceutical companies are hesitant about the benefits of 3D printing and thus Organovo is taking longer to close these deals.<a href=\"#_ftn23\" name=\"_ftnref23\">[23]<\/a> This delay combined with the company spending more and more on R&amp;D has prevented it\u00a0from being profitable, and the longer this continues, the more precarious its\u2019 financial health will become. While Organovo has focused on pharmaceutical companies, it should also try to pitch its technology to more surgeons and hospitals in a bid to increase adoption and grow revenues.<\/li>\n<\/ul>\n<p>Organovo has successful created 3D printed liver and kidney tissue cells. <a href=\"#_ftn24\" name=\"_ftnref24\">[24]<\/a> The company hopes to develop 3D printed versions of entire organs in the future and could, thus, \u00a0provide a boon to patients worldwide waiting for organ transplants. <a href=\"#_ftn25\" name=\"_ftnref25\">[25]<\/a><\/p>\n<p>Could we one day really see 3D printed organs being put into human beings?<\/p>\n<p>&nbsp;<\/p>\n<p>[Word count before references: 789]<\/p>\n<p>References:<\/p>\n<p><a href=\"#_ftnref1\" name=\"_ftn1\">[1]<\/a> http:\/\/www.economist.com\/node\/18114221<\/p>\n<p><a href=\"#_ftnref2\" name=\"_ftn2\">[2]<\/a> http:\/\/additivemanufacturing.com\/basics\/<\/p>\n<p><a href=\"#_ftnref3\" name=\"_ftn3\">[3]<\/a> http:\/\/3dprinting.com\/what-is-3d-printing\/<\/p>\n<p><a href=\"#_ftnref4\" name=\"_ftn4\">[4]<\/a> Ventola, C. Lee. &#8220;Medical applications for 3D printing: current and projected uses.&#8221;\u00a0<em>Pharmacy and Therapeutics<\/em>\u00a039, no. 10 (2014): 704.<\/p>\n<p><a href=\"#_ftnref5\" name=\"_ftn5\">[5]<\/a> http:\/\/www.invetech.com.au\/portfolio\/life-sciences\/3d-bioprinter-world-first-print-human-tissue\/<\/p>\n<p><a href=\"#_ftnref6\" name=\"_ftn6\">[6]<\/a> http:\/\/seekingalpha.com\/article\/3095096-organovo-large-upside-potential-advantages-over-startup-competitors<\/p>\n<p><a href=\"#_ftnref7\" name=\"_ftn7\">[7]<\/a> http:\/\/organovo.com\/science-technology\/bioprinting-process\/<\/p>\n<p><a href=\"#_ftnref8\" name=\"_ftn8\">[8]<\/a> https:\/\/3dprintingindustry.com\/news\/top-10-bioprinters-55699\/<\/p>\n<p><a href=\"#_ftnref9\" name=\"_ftn9\">[9]<\/a> IBID<\/p>\n<p><a href=\"#_ftnref10\" name=\"_ftn10\">[10]<\/a> IBID<\/p>\n<p><a href=\"#_ftnref11\" name=\"_ftn11\">[11]<\/a> http:\/\/organovo.com\/science-technology\/bioprinting-process\/<\/p>\n<p><a href=\"#_ftnref12\" name=\"_ftn12\">[12]<\/a> Ventola, C. Lee. &#8220;Medical applications for 3D printing: current and projected uses.&#8221;\u00a0<em>Pharmacy and Therapeutics<\/em>\u00a039, no. 10 (2014): 704.<\/p>\n<p><a href=\"#_ftnref13\" name=\"_ftn13\">[13]<\/a> http:\/\/www.cnn.com\/2015\/10\/06\/health\/3d-printed-heart-simulated-organs\/<\/p>\n<p><a href=\"#_ftnref14\" name=\"_ftn14\">[14]<\/a> Ventola, C. Lee. &#8220;Medical applications for 3D printing: current and projected uses.&#8221;\u00a0<em>Pharmacy and Therapeutics<\/em>\u00a039, no. 10 (2014): 704.<\/p>\n<p><a href=\"#_ftnref15\" name=\"_ftn15\">[15]<\/a> http:\/\/www.bloomberg.com\/news\/articles\/2015-05-18\/l-oreal-s-plan-to-start-3d-printing-human-skin<\/p>\n<p><a href=\"#_ftnref16\" name=\"_ftn16\">[16]<\/a> http:\/\/organovo.com\/merck-bio-inks-deal-to-use-organovos-3d-printed-liver-for-preclinical-studies\/<\/p>\n<p><a href=\"#_ftnref17\" name=\"_ftn17\">[17]<\/a> Ventola, C. Lee. &#8220;Medical applications for 3D printing: current and projected uses.&#8221;\u00a0<em>Pharmacy and Therapeutics<\/em>\u00a039, no. 10 (2014): 704.<\/p>\n<p><a href=\"#_ftnref18\" name=\"_ftn18\">[18]<\/a> https:\/\/www.marlinwire.com\/blog\/3d-printing-vs-traditional-manufacturing<\/p>\n<p><a href=\"#_ftnref19\" name=\"_ftn19\">[19]<\/a> Campbell, Thomas, Christopher Williams, Olga Ivanova, and Banning Garrett. &#8220;Could 3D printing change the world.&#8221;\u00a0<em>Technologies, Potential, and Implications of Additive Manufacturing, Atlantic Council, Washington, DC<\/em>(2011).<\/p>\n<p><a href=\"#_ftnref20\" name=\"_ftn20\">[20]<\/a> http:\/\/www.forbes.com\/sites\/billconerly\/2014\/11\/05\/the-economics-of-3-d-printing-challenges\/#494ef35a1bc8<\/p>\n<p><a href=\"#_ftnref21\" name=\"_ftn21\">[21]<\/a> https:\/\/hbr.org\/2015\/06\/the-limits-of-3d-printing<\/p>\n<p><a href=\"#_ftnref22\" name=\"_ftn22\">[22]<\/a> http:\/\/www.paristechreview.com\/2014\/04\/10\/industrial-challenges-3d-printing\/<\/p>\n<p><a href=\"#_ftnref23\" name=\"_ftn23\">[23]<\/a> http:\/\/www.fool.com\/investing\/2016\/09\/12\/how-risky-is-organovo-holdings-inc.aspx<\/p>\n<p><a href=\"#_ftnref24\" name=\"_ftn24\">[24]<\/a> http:\/\/www.ibtimes.co.uk\/organovo-ceo-3d-bioprinting-organs-will-help-us-get-people-off-transplant-waiting-lists-1509076<\/p>\n<p><a href=\"#_ftnref25\" name=\"_ftn25\">[25]<\/a> IBID<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"text-decoration: underline\">Sources of Images\/Videos:<\/span><\/p>\n<p><span style=\"text-decoration: underline\">Cover Image:<\/span><\/p>\n<ol>\n<li>http:\/\/3dprinting.com\/wp-content\/uploads\/2013\/07\/Organovo.jpg<\/li>\n<\/ol>\n<p>2.www.3ders.org\/images2016\/organovo-to-develop-transplantable-3d-bioprinted-human-liver-tissue-2.jpg]<\/p>\n<p><span style=\"text-decoration: underline\">Exhibit 1:<\/span><\/p>\n<p>http:\/\/www.economist.com\/news\/technology-quarterly\/21598322-bioprinting-building-living-tissue-3d-printer-becoming-new-business<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=s3CiJ26YS_U-&gt;Video link<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Technology has come a long way in the field of medicine. Could it one day really be used to print entire, fully functional, human organs??<\/p>\n","protected":false},"author":2664,"featured_media":14502,"comment_status":"open","ping_status":"closed","template":"","categories":[1510,1685,2034,1686,2036,2035],"class_list":["post-14501","hck-submission","type-hck-submission","status-publish","has-post-thumbnail","hentry","category-biotechnology","category-medicine","category-organ-printing","category-pharmaceutical","category-surgeon","category-transplant"],"connected_submission_link":"https:\/\/d3.harvard.edu\/platform-rctom\/assignment\/digitization-challenge-2016\/","yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>3D-Bioprinting at Organovo: Effective testing now and maybe organ \u201cprinting\u201d in the future? - Technology and Operations Management<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/d3.harvard.edu\/platform-rctom\/submission\/3d-bioprinting-at-organovo-effective-testing-now-and-maybe-organ-printing-in-the-future\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"3D-Bioprinting at Organovo: Effective testing now and maybe organ \u201cprinting\u201d in the future? - Technology and Operations Management\" \/>\n<meta property=\"og:description\" content=\"Technology has come a long way in the field of medicine. 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